EBOO Therapy (Extracorporeal Blood Oxygenation & Ozonation)
EBOO (Extracorporeal Blood Oxygenation and Ozonation) is an advanced extracorporeal ozone-based procedure that combines ozone therapy, oxygenation support, and continuous blood filtration within a single integrated circulation system. Within integrative and systems-based care environments, EBOO is often regarded as one of the most comprehensive extracorporeal ozone procedures currently available.
During EBOO therapy, blood continuously circulates outside the body through specialized tubing and filtration equipment where it is exposed to controlled oxygen–ozone mixtures before being returned to circulation. Unlike standard MAH or 10-Pass therapy, EBOO incorporates an active filtration component throughout the procedure in addition to repeated ozone exposure and oxygenation support.
Because of its continuous-flow design and ability to process substantially larger circulating blood volumes, EBOO is often utilized when broader systemic ozone exposure, continuous filtration support, oxygenation support, and circulatory processing are desired during treatment.
At NOVA IV Therapy, EBOO procedures are performed under medical supervision using calibrated extracorporeal equipment, sterile protocols, and individualized provider evaluation.
Clinical Considerations & Physiological Role
Continuous-Flow Blood Processing:
Unlike bottle-based MAH or 10-Pass procedures, EBOO continuously circulates blood through an extracorporeal treatment circuit during the session. This continuous-flow design allows substantially larger blood volumes to be processed over time while maintaining ongoing oxygenation and ozone exposure throughout the procedure.
Ozone Diffusion Through a Dialysis-Style Membrane:
Within the EBOO system, ozone is introduced across a specialized dialysis-style membrane rather than directly mixed within a treatment bottle. This membrane-based diffusion process allows ozone to interact continuously with circulating blood components during treatment and is one of the defining characteristics that differentiates EBOO from other ozone delivery methods.
Higher Ozone Uptake & Circulatory Exposure:
Published observations within integrative ozone medicine have suggested that EBOO-style delivery systems may allow significantly greater cumulative ozone uptake compared to traditional pass-based ozone procedures due to the combination of continuous circulation, diffusion-based delivery, and extended treatment duration. These physiologic exposure differences are one reason EBOO is often considered one of the most advanced extracorporeal ozone procedures currently available.
Integrated Filtration & Recovery Physiology:
In addition to ozone exposure and oxygenation support, EBOO incorporates continuous blood filtration throughout the procedure. This combined filtration and circulation approach is one reason some patients pursue EBOO therapy when seeking a more comprehensive extracorporeal ozone procedure for long-standing, complex, or recovery-intensive health concerns.
Common Reasons Patients Explore EBOO Therapy
In integrative medicine settings, EBOO may be explored as a supportive option within a broader, provider-directed plan of care.
Patients may inquire about EBOO in the context of:
- Chronic fatigue and reduced recovery capacity
- Long-standing or difficult-to-resolve health concerns
- Circulatory and cardiovascular wellness goals
- Immune system dysregulation and recovery support
- Neurological, cognitive, or brain fog-related concerns
- Inflammatory and recovery-related support
- Post-viral recovery support
- Environmental stressor and mold-related wellness concerns
- Integrative support strategies for complex or long-standing health concerns
A provider consultation is required to determine whether EBOO may be appropriate based on medical history, current health status, and treatment goals.
Why EBOO Therapy?
Unlike MAH or 10-Pass therapy, which utilize sequential extracorporeal blood treatment cycles, EBOO continuously circulates blood through a combined ozone, oxygenation, and filtration system throughout the duration of the procedure.
This continuous-flow methodology allows for larger circulating blood volumes and integrated filtration support during treatment. The clinical advantages of EBOO therapy include:
- Continuous-Flow Extracorporeal Processing: EBOO continuously circulates blood through a specialized extracorporeal system rather than utilizing repeated bottle-based passes. This continuous circulation model allows blood to undergo ongoing ozone exposure, oxygenation support, and filtration throughout the session.
- Integrated Filtration Component: One of the defining characteristics of EBOO is the incorporation of active blood filtration during treatment. This filtration component is one reason EBOO is sometimes informally referred to as a form of “ozone dialysis,” although it is not equivalent to medical dialysis used for kidney failure.
- Larger Circulating Blood Volumes: Compared to MAH and 10-Pass therapy, EBOO continuously processes substantially larger circulating blood volumes throughout the session. This continuous-flow design allows for ongoing ozone exposure, oxygenation support, and filtration over an extended treatment period, which is one reason EBOO is often regarded as one of the most advanced extracorporeal ozone procedures currently available.
EBOO vs. 10-Pass
Both 10-Pass Ozone and EBOO (Extracorporeal Blood Oxygenation and Ozonation) are advanced ozone-based therapies designed to support circulation, oxygen utilization, immune signaling, and overall physiologic balance.
While both are considered “high-dose” ozone therapies, they work differently and may be selected based on your Provider’s clinical recommendations and your personal wellness goals.
Key Differences
| Feature | 10-Pass Ozone Therapy | EBOO / EBO2 Therapy |
|---|---|---|
| Administration | A "stop-and-go" process where 200ml of blood is drawn, ozonated, and returned 10 times via a single IV. | A continuous, closed-loop circuit where blood is drawn from one arm and returned to the other simultaneously. |
| Blood volume | Typically treats 1.5 to 2 liters of blood. | Can process up to 3 liters of blood — roughly 60% of total body volume. |
| Filtration | No filtration. The focus is solely on the oxidative "spark" of the ozone. | Advanced filtration. Uses a dialysis-like filter to remove heavy metals, inflammatory proteins, and cellular debris. |
| Intensity | Delivers a higher concentration (potency) of ozone in short bursts. | Delivers a larger total volume of ozone more gently, making it often better tolerated for sensitive patients. |
| Treatment Time | Usually takes 60–75 minutes. | Usually takes 60–90 minutes due to the continuous filtration process. |
In General
- MAH involves treating a measured volume of blood outside the body and then reinfusing it.
- 10-Pass repeats that process multiple times during one session.
- EBOO uses a continuous extracorporeal circuit over a longer treatment period.
The appropriate protocol, if any, depends on provider assessment, patient tolerance, and overall treatment planning.
Proudly Serving the D.C., Maryland, Virginia Metro Region
NOVA IV Therapy is conveniently located off Route 7 in Loudoun County, making it easily accessible for patients throughout Sterling, Ashburn, Reston, Herndon, Tysons, Leesburg, Great Falls and the surrounding areas. Designed with comfort and patient experience in mind, our space enables us to offer integrative wellness services and IV therapies in one cohesive environment.
NOVA IV Therapy welcomes patients throughout Northern Virginia, Loudoun County, Fairfax County, and the greater Washington D.C. metro region, including but not limited to: Arlington, Alexandria, Falls Church, Fairfax, Vienna, McLean, Tysons, Reston, Leesburg, Springfield, Herndon, Sterling, Ashburn, Gainesville, Haymarket, Chantilly, Centreville, Clifton, Burke, Great Falls, Oakton, Middleburg, Winchester.
NOVA IV Therapy welcomes patients from Maryland, including but not limited to: Silver Spring, Bethesda, Rockville, Gaithersburg, Germantown, Potomac, Chevy Chase.
Medical & Regulatory Disclaimer
Nutrient IV therapies and ozone-based therapies, including Major Autohemotherapy (MAH), 10-Pass, Extracorporeal Blood Oxygenation and Ozonation (EBOO), ozone limb bagging, and use of the Hemealumen device, are elective wellness services offered under the clinical judgment of licensed providers.
These therapies and protocols are not approved by the U.S. Food and Drug Administration (FDA) for the diagnosis, treatment, cure, or prevention of any disease or medical condition. Statements regarding these services have not been evaluated by the FDA.
These services may be described as investigational, adjunctive, or alternative in nature. No claims are made regarding therapeutic outcomes, efficacy, or specific health benefits, and individual results may vary.
The information provided on this website is for general educational and informational purposes only and is not intended as medical advice. Use of this website does not create a provider–patient relationship. Clinical decisions and medical advice are provided only in the context of an in-person consultation with a licensed healthcare professional.
All medical procedures carry inherent risks. You are responsible for discussing potential risks, benefits, contraindications, and alternatives with a qualified healthcare provider before electing to pursue any service.